Elisabetta
Manduchi
University of Pennsylvania
Department of Genetics
Kaestner Laboratory
12-155 Smilow Center for Translational Research, 3400 Civic Center Blvd, Philadelphia, PA 19104
phone: 215-573-4408; email: manduchi@pennmedicine.upenn.edu
Experience
Education
Research interests
Publications
University of Pennsylvania, Kaestner Laboratory, Department of Genetics
University of Pennsylvania, Computational Genetics Laboratory, Institute for Biomedical Informatics
Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia
University of Pennsylvania, Computational Biology and Informatics Laboratory
University of Pennsylvania, Computational Biology and Informatics Laboratory
Haverford College, Department of Mathematics
University of Pennsylvania, Department of Mathematics
I am a Bioinformatics Scientist, with extensive experience in analysis and management of high-throughput biological data, including development of methods, algorithms, computational tools, functional genomics databases and web resources. I am a former member of the Computational Biology and Informatics Laboratory (CBIL) (UPenn), where I have been involved in several projects including: Beta Cell Genomics (Project Manager), the Rna Abundance Database (RAD) and the Genomics Unified Schema (GUS), PaGE, and Significance Testing for Direct Identity-by-descent mapping (STeDI). As part of CBIL, I have collaborated with many investigators both within and outside of the University of Pennylvania, including a long-term collaboration with Professor Peter Davies' group at UPenn on analyses of high-throughput datasets relative to Cardiovascular Biology. I have also collaborated with Professor Greg Grant's bioinformatics group at ITMAT (UPenn) on methods and code to pre-process and analyze RNA-Seq data. From 2015 to 2019 I have spent half of my time at the Center for Spatial and Functional Genomics at The Children's Hospital of Philadelphia (CHOP), led by Professors Struan Grant and Andrew Wells, where I have worked on integrated analyses of various types of functional genomics data, including high-throughput Chromosome Conformation Capture data. From 2015 to 2021 I was in Professor Jason Moore's Computational Genetics Laboratory in the Institute for Biomedical Informatics at UPenn where I have worked on approaches for identifying genetic and genomic biomarkers associated with human health and disease, embracing the complexity of the genotype-to-phenotype mapping relationship due to phenomena such as epistasis. As of Fall 2021 I am part of Professor Klaus Kaestner's lab (UPenn) where I analyze functional genomics data aimed at elucidating the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract.
Computational Biology/Bioinformatics: Click here for selected list
Mathematics: Click here